Endocrinological Studies of Schizophrenia On the Urinary 17-ketosteroid and 17-hydroxycorticosteroid

17-ketosteroid and 17-hydroxycorticosteroid excretion in patients with duodenal ulceration.

The 24-hour excretion of 17-ketosteroids and 17-hydroxycorticosteroids has been estimated in a series of male duodenal ulcer subjects and compared with that of 56 normal male controls. It has been found that both 17-ketosteroid and 17-hydroxycorticosteroid excretion is less in ulcer subjects than in the control group; these differences are not large but in the case of 17-hydroxycorticosteroids ...

Isolation of urinary 17-ketosteroid conjugates by ammonium sulfate precipitation.

Ammonium sulfate precipitation of urinary 17-ketosteroid conjugates is a rapid, effective method for isolating and purifying them. Negligible quantities of pigment are produced during acid hydrolysis of solutions of the precipitated conjugates. Despite elimination of nonspecific chromogenic material, colorimetric determinations of Zimmerman chromogens with use of the Allen correction of absorba...

Effect of Cortisone on 17-Ketosteroid Excretion *

In 1952 cortisone therapy was initiated in two patients with far advanced prostatic carcinoma.2 As part of the study of those patients, determinations were made of urinary 17-ketosteroid excretion before and during therapy with cortisone. Rather large increases in excretion of 17-ketosteroids were noted during the administration of high doses of cortisone in both patients. This unexpected findi...

17-Hydroxycorticosteroid metabolism in liver disease.

Studies on the chromatographic fractionation of urinary 17-ketosteroid, with special reference to the influence of gonadotropin.

Urinary 17-ketosteroids have been fractionated on alumina column into eight fractions by Dingemanse, et al. (1946)and on a more convenient microscale by Zygmuntowicz, et al. (1951), Pond(1951, 1954)and Edwards, et al. (1953). Using the latter technic, 17-ketosteroids in the urine of young and old people, of men and women, and of castrated people and others have been studied and the relations be...